Drug Classification & Information

Clopidogrel is classified as a platelet aggregation inhibitor (a medication to keep the platelets from sticking together to form a blood clot).  The use of this medication in a liquid formulation is not recommended due to its bitter taste. 

Indications for Use

Clopidogrel is most commonly prescribed for cats with underlying cardiomyopathy who are at risk for clot formation.  It was shown to be superior to aspirin therapy for clot prevention in cats with cardiomyopathy.  The platelet inhibition effects are irreversible.  Withdrawal of the medication revealed normal platelet activity after 7 days.  It is also prescribed in animals with pulmonary hypertension to reduce risk for pulmonary thromboembolism.

Potential Drug Interactions

May increase risk for bleeding when used with aspirin and NSAIDs.  Amlodipine, diltiazem and omeprazole may reduce efficacy of clopidogrel and increase risk for clot formation.  Can be used safely with heparins (enoxaparin).  Clopidogrel may increase blood levels of torsemide.

Drug Side Effects

Clopidogrel is well tolerated.  It is very bitter tasting, so may cause hypersalivation (drooling), vomiting or reduced appetite in treated cats.  High medication dosing may be associated with bruising or bleeding tendencies – monitor for any changes to stool colour (darky, tarry appearance) or vomiting with a coffee ground appearance.

Therapeutic Monitoring

Monitor for evidence of bleeding or other signs of adverse effects.

Dosage Forms

Human: 75, 300 mg tablets (Brand name – Plavix)