Drug Classification & Information
Hyoscyamine is an oral anti-cholinergic. It blocks vagal receptors and is typically used in humans for irritable bowel syndrome. It has similar effects to atropine. Vagal receptors on the heart lead to slower heart rates by affecting the pacemaker of the heart, the sino-atrial (SA) node. Vagal receptors also lead to slower conduction of electrical signals through the atrio-ventricular (AV) node leading to the potential for heart block.
Indications for Use
Occasionally used for the treatment of bradycardias (slow heart rate) in dogs with sick sinus syndrome and AV block.
Potential Drug Interactions
Additive effects can be noted when given with anti-histamines (Benadryl) including urine retention, constipation, arrhythmias and lethargy.
Drug Side Effects
Hyoscyamine can cause pupil dilation, dry eye, constipation, urine retention and tachycardia.
Therapeutic Monitoring
When used for the treatment of bradycardias, regular electrocardiogram (ECG) and Holter monitoring is used to assess treatment efficacy.
Dosage Forms
Human: 0.125 mg tablets
